Metalloproteinases in idiopathic pulmonary fibrosis

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Metalloproteinases in idiopathic pulmonary fibrosis

In this review, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in the disease pathogenesis. Inhibiting metalloproteinases in IPF may therefore have therapeutic potential but our knowledge of their pathophysiologi...

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[Idiopathic Pulmonary Fibrosis].

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and a disease of the elderly. Cigarette smoking and longterm exposure to substances harming alveolar epithelial cells are risk factors for the development of IPF. There is also evidence for a genetic susceptibility. IPF is defined as the idiopathic variant of Usual Interstitial Pneumonitis (UIP). Diagnosis ...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2011

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00024711